Abstract
Composite biomarkers open prospects to combine the targeting advantages of magnetic nanoparticles with direct plasmon-based optical detection of biomolecular interactions. Although nanoparticles from ferromagnetic 3d
-transition metals could be suitable for such a task, they are shown to be rather large, thus tending to agglomerate in aqueous suspensions. A superior alternative uses composite nanoparticles consisting of a superparamagnetic core and a noble metal shell. Systematic Mie-theory based calculations of their plasmon peak shifts and sensitivity against biomolecular binding events on their surfaces are presented for this hybrid particle class.
-transition metals could be suitable for such a task, they are shown to be rather large, thus tending to agglomerate in aqueous suspensions. A superior alternative uses composite nanoparticles consisting of a superparamagnetic core and a noble metal shell. Systematic Mie-theory based calculations of their plasmon peak shifts and sensitivity against biomolecular binding events on their surfaces are presented for this hybrid particle class.
Original language | English |
---|---|
Journal | Applied Physics Letters |
Volume | 93 |
Issue number | 14 |
DOIs | |
Publication status | Published - 6 Oct 2008 |
Externally published | Yes |