Abstract
Composite biomarkers open prospects to combine the targeting advantages of magnetic nanoparticles with direct plasmon-based optical detection of biomolecular interactions. Although nanoparticles from ferromagnetic 3d
-transition metals could be suitable for such a task, they are shown to be rather large, thus tending to agglomerate in aqueous suspensions. A superior alternative uses composite nanoparticles consisting of a superparamagnetic core and a noble metal shell. Systematic Mie-theory based calculations of their plasmon peak shifts and sensitivity against biomolecular binding events on their surfaces are presented for this hybrid particle class.
-transition metals could be suitable for such a task, they are shown to be rather large, thus tending to agglomerate in aqueous suspensions. A superior alternative uses composite nanoparticles consisting of a superparamagnetic core and a noble metal shell. Systematic Mie-theory based calculations of their plasmon peak shifts and sensitivity against biomolecular binding events on their surfaces are presented for this hybrid particle class.
Originalsprache | Englisch |
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Fachzeitschrift | Applied Physics Letters |
Jahrgang | 93 |
Ausgabenummer | 14 |
DOIs | |
Publikationsstatus | Veröffentlicht - 6 Okt. 2008 |
Extern publiziert | Ja |