Progress in Using Magnetic Nanoobjects for Biomedical Diagnostics

Nadezhda Kataeva; Jörg Schotter; Astrit Shoshi; Rudolf Heer; Moritz Eggeling; Ole Bethge; Christa Nöhammer; Hubert Brückl

doi:10.1063/1.2956815

Progress in Using Magnetic Nanoobjects for Biomedical Diagnostics

Nadezhda Kataeva, Jörg Schotter, Astrit Shoshi, Rudolf Heer, Moritz Eggeling, Ole Bethge, Christa Nöhammer, Hubert Brückl

Research output: Contribution to conference (No Proceedings) › Paper

Abstract

A magnetic biochip using the combination of both magnetic nanoobjects as markers and magnetoresistive sensors has proven to be competitive to standard fluorescent DNA‐detection at low concentrations. Magnetic nanoobjects additionally provide the unique possibility to actively manipulate biomolecules, on‐chip, which paves the way to an integrated ‘magnetic lab‐on‐a‐chip’ containing detection and manipulation. It is shown that the hybridization process can be accelerated on a biochip. Looking forward, a paradigm change from the ‘magnetic lab‐on‐a‐chip’ to a ‘magnetic lab‐on‐a‐bead’ is discussed as a future device solution. The ferromagnetic nanoobjects themselves are thereby directly used both as molecular recognition site and as detection unit.

Original language	English
Pages	28-33
DOIs	https://doi.org/10.1063/1.2956815
Publication status	Published - 19 Jun 2008
Externally published	Yes

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10.1063/1.2956815

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title = "Progress in Using Magnetic Nanoobjects for Biomedical Diagnostics",

abstract = "A magnetic biochip using the combination of both magnetic nanoobjects as markers and magnetoresistive sensors has proven to be competitive to standard fluorescent DNA‐detection at low concentrations. Magnetic nanoobjects additionally provide the unique possibility to actively manipulate biomolecules, on‐chip, which paves the way to an integrated {\textquoteleft}magnetic lab‐on‐a‐chip{\textquoteright} containing detection and manipulation. It is shown that the hybridization process can be accelerated on a biochip. Looking forward, a paradigm change from the {\textquoteleft}magnetic lab‐on‐a‐chip{\textquoteright} to a {\textquoteleft}magnetic lab‐on‐a‐bead{\textquoteright} is discussed as a future device solution. The ferromagnetic nanoobjects themselves are thereby directly used both as molecular recognition site and as detection unit.",

author = "Nadezhda Kataeva and J{\"o}rg Schotter and Astrit Shoshi and Rudolf Heer and Moritz Eggeling and Ole Bethge and Christa N{\"o}hammer and Hubert Br{\"u}ckl",

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AU - Kataeva, Nadezhda

AU - Schotter, Jörg

AU - Shoshi, Astrit

AU - Heer, Rudolf

AU - Eggeling, Moritz

AU - Bethge, Ole

AU - Nöhammer, Christa

AU - Brückl, Hubert

PY - 2008/6/19

Y1 - 2008/6/19

N2 - A magnetic biochip using the combination of both magnetic nanoobjects as markers and magnetoresistive sensors has proven to be competitive to standard fluorescent DNA‐detection at low concentrations. Magnetic nanoobjects additionally provide the unique possibility to actively manipulate biomolecules, on‐chip, which paves the way to an integrated ‘magnetic lab‐on‐a‐chip’ containing detection and manipulation. It is shown that the hybridization process can be accelerated on a biochip. Looking forward, a paradigm change from the ‘magnetic lab‐on‐a‐chip’ to a ‘magnetic lab‐on‐a‐bead’ is discussed as a future device solution. The ferromagnetic nanoobjects themselves are thereby directly used both as molecular recognition site and as detection unit.

AB - A magnetic biochip using the combination of both magnetic nanoobjects as markers and magnetoresistive sensors has proven to be competitive to standard fluorescent DNA‐detection at low concentrations. Magnetic nanoobjects additionally provide the unique possibility to actively manipulate biomolecules, on‐chip, which paves the way to an integrated ‘magnetic lab‐on‐a‐chip’ containing detection and manipulation. It is shown that the hybridization process can be accelerated on a biochip. Looking forward, a paradigm change from the ‘magnetic lab‐on‐a‐chip’ to a ‘magnetic lab‐on‐a‐bead’ is discussed as a future device solution. The ferromagnetic nanoobjects themselves are thereby directly used both as molecular recognition site and as detection unit.

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DO - 10.1063/1.2956815

M3 - Paper

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ER -

Progress in Using Magnetic Nanoobjects for Biomedical Diagnostics

Abstract

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