Real time quantitative in-situ DNA hybridization via microcantilever arrays in liquid

Annalisa De Pastina; Giulio Brunetti; Martin Hegner

Real time quantitative in-situ DNA hybridization via microcantilever arrays in liquid

Annalisa De Pastina, Giulio Brunetti, Martin Hegner

Publikation: Konferenzband/Beitrag in Buch/Bericht › Konferenzartikel › Begutachtung

Abstract

This work reports, for the first time, real time quantitative label-free in-situ detection of DNA hybridization via microcantilevers array in liquid. We present a nanomechanical assay based on Silicon microcantilevers array with 18 resonators, enabling sub-nM detection of nucleic acids in liquid environment. The presence of several cantilevers allows differential read out among multiple sensors functionalized with different biomolecules, thus providing internal control towards unspecific binding and environmental variations.

Originalsprache	Englisch
Titel	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2021)
Publikationsstatus	Veröffentlicht - Okt. 2021
Extern publiziert	Ja

Andere Dateien und Links

https://microtas2021.org/

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title = "Real time quantitative in-situ DNA hybridization via microcantilever arrays in liquid",

abstract = "This work reports, for the first time, real time quantitative label-free in-situ detection of DNA hybridization via microcantilevers array in liquid. We present a nanomechanical assay based on Silicon microcantilevers array with 18 resonators, enabling sub-nM detection of nucleic acids in liquid environment. The presence of several cantilevers allows differential read out among multiple sensors functionalized with different biomolecules, thus providing internal control towards unspecific binding and environmental variations.",

author = "{De Pastina}, Annalisa and Giulio Brunetti and Martin Hegner",

year = "2021",

month = oct,

language = "English",

booktitle = "25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2021)",

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T1 - Real time quantitative in-situ DNA hybridization via microcantilever arrays in liquid

AU - De Pastina, Annalisa

AU - Brunetti, Giulio

AU - Hegner, Martin

PY - 2021/10

Y1 - 2021/10

N2 - This work reports, for the first time, real time quantitative label-free in-situ detection of DNA hybridization via microcantilevers array in liquid. We present a nanomechanical assay based on Silicon microcantilevers array with 18 resonators, enabling sub-nM detection of nucleic acids in liquid environment. The presence of several cantilevers allows differential read out among multiple sensors functionalized with different biomolecules, thus providing internal control towards unspecific binding and environmental variations.

AB - This work reports, for the first time, real time quantitative label-free in-situ detection of DNA hybridization via microcantilevers array in liquid. We present a nanomechanical assay based on Silicon microcantilevers array with 18 resonators, enabling sub-nM detection of nucleic acids in liquid environment. The presence of several cantilevers allows differential read out among multiple sensors functionalized with different biomolecules, thus providing internal control towards unspecific binding and environmental variations.

UR - https://microtas2021.org/

M3 - Conference Paper

BT - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2021)

ER -

Real time quantitative in-situ DNA hybridization via microcantilever arrays in liquid

Abstract

Andere Dateien und Links

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