Progress in using magnetic nanoobjects for biomedical diagnostics

N. Kataeva; J. Schotter; A. Shoshi; R. Heer; M. Eggeling; O. Bethge; C. Nöhammer; H. Brückl

doi:10.1063/1.2956815

Progress in using magnetic nanoobjects for biomedical diagnostics

N. Kataeva, J. Schotter, A. Shoshi, R. Heer, M. Eggeling, O. Bethge, C. Nöhammer, H. Brückl

Research output: Contribution to conference (No Proceedings) › Paper › peer-review

Abstract

A magnetic biochip using the combination of both magnetic nanoobjects as markers and magnetoresistive sensors has proven to be competitive to standard fluorescent DNA-detection at low concentrations. Magnetic nanoobjects additionally provide the unique possibility to actively manipulate biomolecules, on-chip, which paves the way to an integrated 'magnetic lab-on-a-chip' containing detection and manipulation. It is shown that the hybridization process can be accelerated on a biochip. Looking forward, a paradigm change from the 'magnetic lab-on-a-chip' to a 'magnetic lab-on-a-bead' is discussed as a future device solution. The ferromagnetic nanoobjects themselves are thereby directly used both as molecular recognition site and as detection unit. © 2008 American Institute of Physics.

Original language	English
Pages	28-33
DOIs	https://doi.org/10.1063/1.2956815
Publication status	Published - 2008
Externally published	Yes

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AU - Schotter, J.

AU - Shoshi, A.

AU - Heer, R.

AU - Eggeling, M.

AU - Bethge, O.

AU - Nöhammer, C.

AU - Brückl, H.

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AB - A magnetic biochip using the combination of both magnetic nanoobjects as markers and magnetoresistive sensors has proven to be competitive to standard fluorescent DNA-detection at low concentrations. Magnetic nanoobjects additionally provide the unique possibility to actively manipulate biomolecules, on-chip, which paves the way to an integrated 'magnetic lab-on-a-chip' containing detection and manipulation. It is shown that the hybridization process can be accelerated on a biochip. Looking forward, a paradigm change from the 'magnetic lab-on-a-chip' to a 'magnetic lab-on-a-bead' is discussed as a future device solution. The ferromagnetic nanoobjects themselves are thereby directly used both as molecular recognition site and as detection unit. © 2008 American Institute of Physics.

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ER -

Progress in using magnetic nanoobjects for biomedical diagnostics

Abstract

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