TY - JOUR
T1 - Magnetoresistive sensors and magnetic nanoparticles for biotechnology
AU - Reiss, Guenter
AU - Brueckl, Hubert
AU - Huetten, Andreas
AU - Schotter, Joerg
AU - Brzeska, Monika
AU - Panhorst, Michael
AU - Sudfeld, Daniela
AU - Becker, Anke
AU - Kamp, Paul b.
AU - Puehler, Alfred
AU - Wojczykowski, Klaus
AU - Jutzi, Peter
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Magnetoresistive biosensors use a new detection method for molecular recognition reactions based on two recently developed techniques and devices: Magnetic markers and XMR sensors, where XMR means either giant magnetoresistance (GMR) or tunneling magnetoresistance (TMR). The markers are specifically attached to the target molecules, and their magnetic stray field is picked up by an embedded magnetoresistive sensor as a change of the electrical resistance. Compared to established, e.g., fluorescent, detection methods, magnetic biosensors have a number of advantages, including low molecular detection limits, flexibility, and the direct availability of an electronic signal suitable for further automated analysis. This makes them a promising choice for the detection units of future widespread and easy-to-use lab-on-a-chip systems or biochips. In this article, we discuss recent advances in this field and compare possible approaches toward single molecule detection.
AB - Magnetoresistive biosensors use a new detection method for molecular recognition reactions based on two recently developed techniques and devices: Magnetic markers and XMR sensors, where XMR means either giant magnetoresistance (GMR) or tunneling magnetoresistance (TMR). The markers are specifically attached to the target molecules, and their magnetic stray field is picked up by an embedded magnetoresistive sensor as a change of the electrical resistance. Compared to established, e.g., fluorescent, detection methods, magnetic biosensors have a number of advantages, including low molecular detection limits, flexibility, and the direct availability of an electronic signal suitable for further automated analysis. This makes them a promising choice for the detection units of future widespread and easy-to-use lab-on-a-chip systems or biochips. In this article, we discuss recent advances in this field and compare possible approaches toward single molecule detection.
U2 - 10.1557/jmr.2005.0409
DO - 10.1557/jmr.2005.0409
M3 - Article
SN - 0884-2914
VL - 20
SP - 3294
EP - 3302
JO - Journal of Materials Research
JF - Journal of Materials Research
IS - 12
ER -