Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

Gianfranco Decandia; PALUMBO FABIO; Annalisa Treglia; Vincenza Armenise; Pietro Favia; BARUZZI FEDERICO; Katrin Unger; Alberto Perrotta; Anna Maria Coclite

doi:10.3390/pharmaceutics12030213

Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

Gianfranco Decandia, PALUMBO FABIO, Annalisa Treglia, Vincenza Armenise, Pietro Favia, BARUZZI FEDERICO, Katrin Unger, Alberto Perrotta, Anna Maria Coclite

Research output: Contribution to journal › Article › peer-review

Abstract

A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.

Original language	English
Journal	Pharmaceutics
DOIs	https://doi.org/10.3390/pharmaceutics12030213
Publication status	Published - 1 Mar 2020
Externally published	Yes

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title = "Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery",

abstract = "A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.",

author = "Gianfranco Decandia and PALUMBO FABIO and Annalisa Treglia and Vincenza Armenise and Pietro Favia and BARUZZI FEDERICO and Katrin Unger and Alberto Perrotta and Coclite, {Anna Maria}",

year = "2020",

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doi = "10.3390/pharmaceutics12030213",

language = "English",

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T1 - Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

AU - Decandia, Gianfranco

AU - FABIO, PALUMBO

AU - Treglia, Annalisa

AU - Armenise, Vincenza

AU - Favia, Pietro

AU - FEDERICO, BARUZZI

AU - Unger, Katrin

AU - Perrotta, Alberto

AU - Coclite, Anna Maria

PY - 2020/3/1

Y1 - 2020/3/1

N2 - A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.

AB - A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.

UR - http://dx.doi.org/10.3390/pharmaceutics12030213

U2 - 10.3390/pharmaceutics12030213

DO - 10.3390/pharmaceutics12030213

M3 - Article

SN - 1999-4923

JO - Pharmaceutics

JF - Pharmaceutics

ER -

Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

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