Abstract
We present design criteria, operation principles and experimental examples of magnetic marker manipulation for our magnetic lab-on-a-chip prototype. It incorporates both magnetic sample preparation and detection by embedded GMR-type magnetoresistive sensors and is optimized for the automated point-of-care detection of four different sepsis-indicative cytokines directly from about 5 μl of whole blood. The sample volume, magnetic particle size and cytokine concentration determine the microfluidic volume, sensor size and dimensioning of the magnetic gradient field generators. By optimizing these parameters to the specific diagnostic task, best performance is expected with respect to sensitivity, analysis time and reproducibility.
Original language | English |
---|---|
Pages (from-to) | 1671-1675 |
Journal | Journal of Magnetism and Magnetic Materials |
Volume | 321 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 May 2009 |
Externally published | Yes |