Detection and manipulation of biomolecules by magnetic carriers

M Brzeska; M Panhorst; P.b Kamp; J Schotter; G Reiss; A Pühler; A Becker; H Brückl

doi:10.1016/j.jbiotec.2004.04.018

Detection and manipulation of biomolecules by magnetic carriers

M Brzeska, M Panhorst, P.b Kamp, J Schotter, G Reiss, A Pühler, A Becker, H Brückl

Research output: Contribution to journal › Article › peer-review

Abstract

The detection and manipulation of single molecules on a common platform would be of great interest for basic research of biological or chemical systems. A promising approach is the application of magnetic carriers. The principles are demonstrated in this contribution. It is shown that paramagnetic beads can be detected by highly sensitive magnetoresistive sensors yielding a purely electronic signal. Different configurations are discussed. The capability of the sensors to detect even single markers is demonstrated by a model experiment. In addition, the paramagnetic beads can be used as carriers for biomolecules. They can be manipulated on-chip via currents running through specially designed line patterns. Thus, magnetic markers in combination with magnetoresistive sensors are a promising choice for future integrated lab-on-a-chip systems.

Original language	English
Pages (from-to)	25-33
Journal	Journal of Biotechnology
Volume	112
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jbiotec.2004.04.018
Publication status	Published - 1 Aug 2004
Externally published	Yes

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10.1016/j.jbiotec.2004.04.018

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title = "Detection and manipulation of biomolecules by magnetic carriers",

abstract = "The detection and manipulation of single molecules on a common platform would be of great interest for basic research of biological or chemical systems. A promising approach is the application of magnetic carriers. The principles are demonstrated in this contribution. It is shown that paramagnetic beads can be detected by highly sensitive magnetoresistive sensors yielding a purely electronic signal. Different configurations are discussed. The capability of the sensors to detect even single markers is demonstrated by a model experiment. In addition, the paramagnetic beads can be used as carriers for biomolecules. They can be manipulated on-chip via currents running through specially designed line patterns. Thus, magnetic markers in combination with magnetoresistive sensors are a promising choice for future integrated lab-on-a-chip systems.",

author = "M Brzeska and M Panhorst and P.b Kamp and J Schotter and G Reiss and A P{\"u}hler and A Becker and H Br{\"u}ckl",

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T1 - Detection and manipulation of biomolecules by magnetic carriers

AU - Brzeska, M

AU - Panhorst, M

AU - Kamp, P.b

AU - Schotter, J

AU - Reiss, G

AU - Pühler, A

AU - Becker, A

AU - Brückl, H

PY - 2004/8/1

Y1 - 2004/8/1

N2 - The detection and manipulation of single molecules on a common platform would be of great interest for basic research of biological or chemical systems. A promising approach is the application of magnetic carriers. The principles are demonstrated in this contribution. It is shown that paramagnetic beads can be detected by highly sensitive magnetoresistive sensors yielding a purely electronic signal. Different configurations are discussed. The capability of the sensors to detect even single markers is demonstrated by a model experiment. In addition, the paramagnetic beads can be used as carriers for biomolecules. They can be manipulated on-chip via currents running through specially designed line patterns. Thus, magnetic markers in combination with magnetoresistive sensors are a promising choice for future integrated lab-on-a-chip systems.

AB - The detection and manipulation of single molecules on a common platform would be of great interest for basic research of biological or chemical systems. A promising approach is the application of magnetic carriers. The principles are demonstrated in this contribution. It is shown that paramagnetic beads can be detected by highly sensitive magnetoresistive sensors yielding a purely electronic signal. Different configurations are discussed. The capability of the sensors to detect even single markers is demonstrated by a model experiment. In addition, the paramagnetic beads can be used as carriers for biomolecules. They can be manipulated on-chip via currents running through specially designed line patterns. Thus, magnetic markers in combination with magnetoresistive sensors are a promising choice for future integrated lab-on-a-chip systems.

U2 - 10.1016/j.jbiotec.2004.04.018

DO - 10.1016/j.jbiotec.2004.04.018

M3 - Article

SN - 0168-1656

VL - 112

SP - 25

EP - 33

JO - Journal of Biotechnology

JF - Journal of Biotechnology

IS - 1-2

ER -

Detection and manipulation of biomolecules by magnetic carriers

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