Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach

Hubert Brueckl, Astrit Shoshi, Stefan Schrittwieser, Barbara Schmid, Pia Schneeweiss, Tina Mitteramskogler, Michael Haslinger, Michael Muehlberger, Joerg Schotter

Research output: Contribution to journalArticlepeer-review

Abstract

Multifunctional nanoparticles are discussed as versatile probes for homogeneous immunoassays for in-vitro diagnostics. Top-down fabrication allows to combine and tailor magnetic and plasmonic anisotropic properties. The combination of nanoimprint lithography, thin film deposition, and lift-off processing provides a top-down fabrication platform, which is both flexible and reliable. Here, we discuss the material compositions and geometrical designs of monodisperse multicomponent nanoparticles and their consequences on optical and magnetic properties. The rotational hydrodynamics of nanoparticles is measured and considered under the influence of magnetic shape anisotropy in the framework of the Stoner-Wohlfarth theory. The plasmon-optical properties are explained by discrete-dipole finite-element simulations. Rotational dynamical measurements of imprinted nanoprobes for two test proteins demonstrate the applicability as highly sensitive biomolecular nanoprobes.
Original languageEnglish
Article number6039
JournalScientific Reports
Volume11
Issue number1
DOIs
Publication statusPublished - 16 Mar 2021
Externally publishedYes

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