TY - JOUR
T1 - Iron-Based Core-Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy
AU - Martínez-Banderas, Aldo Isaac
AU - Aires, Antonio
AU - Quintanilla, Marta
AU - Holguín-Lerma, Jorge A.
AU - Lozano-Pedraza, Claudia
AU - Teran, Francisco J.
AU - Moreno, Julián A.
AU - Perez, Jose E.
AU - Ooi, Boon S.
AU - Ravasi, Timothy
AU - Merzaban, Jasmeen S.
AU - Cortajarena, Aitziber L.
AU - Kosel, Jürgen
PY - 2019/11/27
Y1 - 2019/11/27
N2 - Combining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core-shell nanostructure features an enhanced light-matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death (∼90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments.
AB - Combining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core-shell nanostructure features an enhanced light-matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death (∼90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments.
KW - drug delivery
KW - iron-iron oxide core-shell
KW - magnetic cancer therapy
KW - nanowires
KW - photothermal therapy
UR - https://www.mendeley.com/catalogue/4778ebc7-e003-3281-bce3-7c987c2b630b/
U2 - 10.1021/acsami.9b17512
DO - 10.1021/acsami.9b17512
M3 - Article
C2 - 31682404
SN - 1944-8252
VL - 11
SP - 43976
EP - 43988
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 47
ER -