Beschreibung
Electrochemical sensing platforms including nanostructured materials have attracted increasing attention for diagnostic applications in recent decades. People in resource-limited places, particularly in low- and middle-income countries, continue to face problems finding high-quality medical treatment and technologies. The use of LSG sensors for diagnostic purposes has been gaining attention [1]. Point-of-care (PoC) diagnostic technologies are in high demand for early diagnosis due to their ability to analyze a biological event directly from a real sample by displaying the result without any further sample processing or expertise [2]. Compared to established methods for graphene synthesis, laser scribing provides many advantages, such as cost-effectiveness, fast electron mobility, mask-free production, green synthesis, good electrical conductivity, porosity, mechanical stability, and large surface area. The electrodeposition technique was chosen to enhance the electrocatalytic activity with high surface coverage, higher sensitivity, and ease of surface modification. We also focused on possible surface activation techniques on LSG electrodes to achieve an enhancement in surface area through electrochemical strategies [3]. LSG-AuNS electrodes are realized by electrodeposition of gold chloride (HAuCl4) solution, which gave~2-fold enhancement in sensitivity and electrocatalytic activity compared to bare LSG electrode. Moreover, we focus on surface functionalization methods for the development of self-diagnostic devices. LSG based electrochemical sensors have been applied to screening of acute myocardial infarction and human epidermal growth factor receptor 2 (Her-2) biomarker detection for breast cancer screening. As a readout system, we developed a portable potentiostat with smartphone application, called KAUSTat. Together with a customized smartphone app and Bluetooth connection, this point of care diagnostic platform has the potential to replace costly health care instrumentation with simple and practical miniaturized smart systems [4].Keywords: Biosensorspoint-of-care diagnosticsLaser-scribed grapheneelectrochemical sensorsaffinity sensors
References:
Lahcen, A. A., Rauf, S., Beduk, T., Durmus, C., Aljedaibi, A., Timur, S., Salama, K. N. (2020). Biosensors and Bioelectronics, 168, 112565.
Rauf, S., Lahcen, A. A., Aljedaibi, A., Beduk, T., de Oliveira Filho, J. I., & Salama, K. N. (2021). Biosensors and Bioelectronics, 180, 113116.
Ghanam, A., Lahcen, A. A., Beduk, T., Alshareef, H. N., Amine, A., & Salama, K. N. (2020). Biosensors and Bioelectronics, 168, 112509.
Beduk, T., Beduk, D., de Oliveira Filho, J. I., Zihnioglu, F., Cicek, C.,Timur, S. (2021). Analytical chemistry, 93(24), 8585-8594.
| Zeitraum | 8 Sep. 2022 |
|---|---|
| Ereignistitel | 16th Nanoscience and Nanotechnology Conference |
| Veranstaltungstyp | Konferenz |
| Ort | Ankara, TürkeiAuf Karte anzeigen |
| Bekanntheitsgrad | International |